2. Academic Validation
  3. MAD1 deficiency accelerates hepatocellular proliferation via suppressing TGF-β signaling

MAD1 deficiency accelerates hepatocellular proliferation via suppressing TGF-β signaling

  • Heliyon. 2024 May 15;10(10):e31312. doi: 10.1016/j.heliyon.2024.e31312.
Jiangming Deng 1 2 3,  Jianhui Teng 1 2,  Ting Xiao 2 4,  Jie Wen 5,  Wen Meng 1 2 6
Affiliations

Affiliations

  • 1 National Clinical Research Center for Metabolic Diseases and the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
  • 2 The Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
  • 3 Departments of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
  • 4 Department of Hepatology, Hunan Children's Hospital, Changsha, 410000, Hunan, China.
  • 5 Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, 410008, China.
  • 6 Departments of Oncology, the Second Xiangya Hospital of Central South University, Changsha, 410011, Hunan, China.
PMID: 38813231 DOI: 10.1016/j.heliyon.2024.e31312
Abstract

Numerous researches have reported on the regulatory network of liver regeneration induced by partial hepatectomy (PH). However, information on key molecules and/or signaling pathways regulating the termination stage of liver regeneration remains limited. In this study, we identify hepatic mitotic arrest deficient 1 (MAD1) as a crucial regulator of transforming growth factor β (TGF-β) in the hepatocyte to repress liver regeneration. MAD1 has a low expression level at the rapid proliferation phase but significantly increases at the termination phase of liver regeneration. We show that MAD1 deficiency accelerates hepatocyte proliferation and enhances mitochondrial biogenesis and respiratory. Mechanistically, MAD1 deficiency in hepatocytes enhances mitochondrial function and promotes hepatocyte proliferation by suppressing TGF-β signaling. Our study reveals MAD1 as a novel suppressor of hepatocyte proliferation, which may provide a new therapeutic target for the recovery of liver function after liver transplant and partial hepatectomy.

Keywords

Hepatocyte proliferation; Liver regeneration; MAD1; Mitochondrial function; TGF-β signaling.

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