2. Academic Validation
  3. Sustained but Decoyed Activation of the JAK1-STAT Pathway by Aberrant Protein Aggregation Exacerbates Proteotoxicity

Sustained but Decoyed Activation of the JAK1-STAT Pathway by Aberrant Protein Aggregation Exacerbates Proteotoxicity

  • Circulation. 2024 Oct 15;150(16):1302-1305. doi: 10.1161/CIRCULATIONAHA.124.070067.
Mingqi Cai 1,  Bo Pan 1,  Peng Xiao 1,  Mark Bouska 1,  Megan T Lewno 1,  Yu Xing 2,  Erliang Zeng 3,  Huiyun Liang 4,  Faqian Li 4 5,  Xiang Gao 6,  Xuejun Wang 1
Affiliations

Affiliations

  • 1 Division of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion (M.C., B.P., P.X., M.B., M.T.L., X.W.).
  • 2 Department of Computer Science, Loyola University Chicago, IL (Y.X.).
  • 3 Division of Biostatistics and Computational Biology, University of Iowa College of Dentistry, Iowa City (E.Z.).
  • 4 Department of Pathology and Laboratory Medicine, Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health Science Center at San Antonio (H.L., F.L.).
  • 5 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (F.L.).
  • 6 Department of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL (X.G.).
PMID: 39401278 DOI: 10.1161/CIRCULATIONAHA.124.070067
Abstract

Aberrant protein aggregation hijacks phosphorylated STATs and decoys the JAK1-STAT pathway to exacerbate proteotoxicity.

Keywords

Janus kinase 1; Janus kinase inhibitors; STAT transcription factors; proteasome endopeptidase complex; protein aggregation, pathological; proteostasis deficiencies; ubiquitin.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-16997
    99.97%, JAK1 Inhibitor
    JAK