2. Academic Validation
  3. Triptophenolide Improves Rheumatoid Arthritis and Progression by Inducing Macrophage Toxicity

Triptophenolide Improves Rheumatoid Arthritis and Progression by Inducing Macrophage Toxicity

  • J Biochem Mol Toxicol. 2025 Jan;39(1):e70096. doi: 10.1002/jbt.70096.
Xiuxiu Pu 1 2,  Qiao Ye 1
Affiliations

Affiliations

  • 1 Rheumatology and Immunology Department, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
  • 2 Jiaxing University Graduate Joint Training Center, Zhejiang Chinese Medical University, Jiaxing, China.
PMID: 39722460 DOI: 10.1002/jbt.70096
Abstract

To investigate the role and mechanism of triptophenolide (TRI) in resisting rheumatoid arthritis (RA). Network pharmacology analysis results suggested that TRI was related to multiple inflammation-related signaling proteins, and possessed the stable structural configuration. In animal experiments, TRI suppressed RA in mice, inhibited tissue inflammation, and improved synovial injury. Moreover, TRI can suppress RA via multiple signaling pathways, and inhibiting Pyroptosis is one of the feasible treatments for improving RA.

Keywords

network pharmacology; pyroptosis; rheumatoid arthritis; triptophenolide.

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