2. Academic Validation
  3. Effect of perioperative analgesia on immunity in lung cancer

Effect of perioperative analgesia on immunity in lung cancer

  • Immunobiology. 2025 Mar;230(2):152867. doi: 10.1016/j.imbio.2025.152867.
Xiaomin Fan 1,  Ziqi Huang 1,  Ziying Chen 2,  Liang Yun 3,  Xinjian Zhang 4
Affiliations

Affiliations

  • 1 Department of Anesthesiology, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 2 Department of Radiation Oncology, Shenzhen Longgang Central Hospital of Shenzhen, Shenzhen, China.
  • 3 The first clinical medical college, Southern Medical University, Guangzhou, China.
  • 4 Department of Anesthesiology, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address: [email protected].
PMID: 39847998 DOI: 10.1016/j.imbio.2025.152867
Abstract

COX inhibitors are frequently used for pain management during the perioperative period and may influence tumor progression and the tumor microenvironment by modulating inflammation and immune responses. This study investigates the effects of COX inhibitors on tumor growth and the immune microenvironment. In vivo experiments demonstrate that COX inhibitors can reduce tumor cell growth, elevate PD-L1 expression on tumor cells, and enhance the proportion of myeloid cells within the tumor immune microenvironment. Furthermore, COX inhibitors are found to improve the efficacy of the immune checkpoint inhibitor anti-PD-L1. These results underscore the influence of perioperative COX inhibitors on tumor immunity and suggest potential new strategies for optimizing tumor immunotherapy.

Keywords

COX inhibitor; Immune checkpoint; Lung adenocarcinoma; Perioperative analgesia; Tumor microenvironment.

Figures
Products