2. Academic Validation
  3. Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells

Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells

  • PLoS One. 2025 Apr 30;20(4):e0320154. doi: 10.1371/journal.pone.0320154.
Yu-Cheng Chen 1 2,  Wei-Cheng Tsai 3,  Zhi-Xiang Li 3,  Wan-Jung Lin 3,  Hao-Yu Lin 3,  Yi-Ju Hsieh 3,  Kai-Hsuan Wang 3,  You-Yan Chen 4,  Tsong-Long Hwang 1 2 5 6 7,  Tzou-Yien Lin 8
Affiliations

Affiliations

  • 1 Center for Drug Research and Development, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
  • 2 Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
  • 3 ExoOne Bio Co., Ltd., Taipei City, Taiwan.
  • 4 School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • 5 Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City, Taiwan.
  • 6 Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
  • 7 Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
  • 8 Department of Paediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.
PMID: 40305498 DOI: 10.1371/journal.pone.0320154
Abstract

Human hair dermal papilla cells (HHDPCs) play a significant role in hair growth. This study found that human umbilical cord mesenchymal stem cell-derived exosomes (UC-MSC-Es) effectively enhanced cell growth of HHDPCs. UC-MSC-Es has a size range of 30-180 nm and expression of CD9, CD63, CD81, CD73, and TSG101. UC-MSC-Es significantly increased cell populations of HHDPCs in the S and G2/M phases. UC-MSC-Es also increased the expression of cell cycle-related proteins, β-catenin, and cyclin D1. Further mechanistic studies demonstrated that UC-MSC-Es promoted the phosphorylation of Akt and GSK-3β, and the inhibition of PI3K and Akt reduced the proliferative effects of UC-MSC-Es. Collectively, these findings suggest that UC-MSC-Es have a potential effect in treating hair loss through modulating PI3K and Akt-dependent pathways in HHDPCs.

Figures
Products