2. Academic Validation
  3. Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics

Safety Assessment of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid as Used in Cosmetics

  • Int J Toxicol. 2025 Dec;44(4_suppl):82S-92S. doi: 10.1177/10915818251344597.
Christina L Burnett 1,  Wilma F Bergfeld 2,  Donald V Belsito 2,  David E Cohen 2,  Curtis D Klaassen 2,  Daniel C Liebler 3,  James G Marks 3,  Lisa A Peterson 3,  Ronald C Shank 3,  Thomas J Slaga 3,  Paul W Snyder 2,  Monice M Fiume 4,  Bart Heldreth 5
Affiliations

Affiliations

  • 1 Cosmetic Ingredient Review Former Senior Scientific Analyst/Writer.
  • 2 Expert Panel for Cosmetic Ingredient Safety Member.
  • 3 Expert Panel for Cosmetic Ingredient Safety Former Member.
  • 4 Cosmetic Ingredient Review Senior Director.
  • 5 Cosmetic Ingredient Review Executive Director.
PMID: 41104883 DOI: 10.1177/10915818251344597
Abstract

The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Tetrasodium Glutamate Diacetate and Beta-Alanine Diacetic Acid, which are reported to function as Chelating Agents in cosmetic products. The Panel reviewed the available data to determine the safety of these ingredients. The Panel concluded that Tetrasodium Glutamate Diacetate is safe in cosmetics in the practices of use and concentration described in this safety assessment, and that the available data are insufficient to make a determination that Beta-Alanine Diacetic Acid is safe under the intended conditions of use in cosmetic formulations.

Keywords

Beta-Alanine Diacetic Acid; Cosmetic Ingredient Review; Cosmetics; Expert Panel for Cosmetic Ingredient Safety; Safety; Tetrasodium Glutamate Diacetate.

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