2. Academic Validation
  3. Prevention of acute thrombosis with vascular endothelium antioxidative nanoscavenger

Prevention of acute thrombosis with vascular endothelium antioxidative nanoscavenger

  • Nat Nanotechnol. 2025 Oct 31. doi: 10.1038/s41565-025-02046-4.
Yixin Zhong # 1 2 3,  Qiankun Ni # 3 4 5,  Liandi Huang # 2,  Guangchao Qing # 3,  Fuxue Zhang 3,  Ningqiang Gong 6,  Hongyun Wu 2,  Yukun Liao 2,  Huiting Jiang 2,  Zaiqian Tu 3,  Zhifei Wang 3,  Luksika Jiramonai 3,  Haidong Zhu 1,  Gao-Jun Teng 7,  Xing-Jie Liang 8 9
Affiliations

Affiliations

  • 1 Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital & Basic Medicine Research and Innovation Center of Ministry of Education, Southeast University, Nanjing, China.
  • 2 Chongqing Key Laboratory of Ultrasound Molecular Imaging & Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • 3 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China.
  • 4 Department of Chemistry, Center for BioAnalytical Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, China.
  • 5 Beijing Life Science Academy, Beijing, China.
  • 6 Department of General Surgery, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China.
  • 7 Center of Interventional Radiology and Vascular Surgery, Department of Radiology, Zhongda Hospital & Basic Medicine Research and Innovation Center of Ministry of Education, Southeast University, Nanjing, China. [email protected].
  • 8 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China. [email protected].
  • 9 University of Chinese Academy of Sciences, Beijing, China. [email protected].
  • # Contributed equally.
PMID: 41174280 DOI: 10.1038/s41565-025-02046-4
Abstract

Antiplatelet drugs have represented a milestone in treating patients at high risk of thrombosis. However, their clinical use remains limited by bleeding-associated risk and limited efficacy. Excessive Reactive Oxygen Species (ROS) produced by damaged vascular endothelial cells have been shown to stimulate thrombosis. Here we propose that a ROS-chemotactic nanoscavenger (MDCP), formed by crosslinking melanin and catalase, prevents acute thrombosis by protecting vascular endothelial cells from oxidative stress. We demonstrate that treatment with MDCP inhibits ROS-induced Apoptosis of endothelial cells, thereby maintaining endothelial integrity and preventing Collagen exposure, which consequently prevents platelet activation and thrombosis. By avoiding direct interference with platelet function, this modulation of vascular redox homeostasis via MDCP provides a promising alternative antithrombotic strategy that addresses the bleeding risk of current clinical antithrombotic drugs.

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