2. Academic Validation
  3. Design and Synthesis of Novel USP1 Inhibitors for Therapeutic Applications

Design and Synthesis of Novel USP1 Inhibitors for Therapeutic Applications

  • ACS Med Chem Lett. 2025 Oct 30;16(11):2197-2199. doi: 10.1021/acsmedchemlett.5c00627.
Danielle E Hoyle 1,  Steven H Liang 1
Affiliations

Affiliation

  • 1 Department of Radiology and Imaging Sciences, Emory University, 1364 Clifton Road, Atlanta, Georgia 30322, United States.
PMID: 41256996 DOI: 10.1021/acsmedchemlett.5c00627
Abstract

The present invention details novel inhibitors of Ubiquitin-Specific Protease 1 (USP1) and their pharmaceutically acceptable forms, compositions, and methods of use. These compounds demonstrate therapeutic potential for the treatment and prevention of USP1-related diseases, either as single agents or in combination with additional therapeutic agents.

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