2. Academic Validation
  3. Lactic Acid Alleviates Cow's Milk Allergy by Regulating Regulatory T Cells and Intestinal Microbiota

Lactic Acid Alleviates Cow's Milk Allergy by Regulating Regulatory T Cells and Intestinal Microbiota

  • J Agric Food Chem. 2025 Dec 17;73(50):32236-32249. doi: 10.1021/acs.jafc.5c02986.
Ruofan Xie 1 2 3,  Yan Liu 1 2 3,  Xin Liu 1 2 3,  Fan Yang 1 2 3,  Siqi Fu 1 2 3,  Hongbing Chen 1 3 4,  Xin Li 1 2 3
Affiliations

Affiliations

  • 1 State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, P.R. China.
  • 2 College of Food Science and Technology, Nanchang University, Nanchang 330047, P.R. China.
  • 3 Jiangxi Provincial Key Laboratory of Food Allergy, Nanchang University, Nanchang 330047, P.R. China.
  • 4 Sino German Joint Research Institute, Nanchang University, 235 Nanjing Dong Road, Nanchang, Jiangxi 330047, China.
PMID: 41359930 DOI: 10.1021/acs.jafc.5c02986
Abstract

Cow's milk allergy (CMA) is common in early childhood, and the incidence is increasing. As a precursor of short-chain fatty acids, lactic acid holds great potential in the treatment of CMA. The β-lactoglobulin-induced food allergy mice model was established, and lactic acid was added at different times to explore its antiallergic activity. The LA-Pre group (lactic acid administered before sensitization) significantly decreased the levels of immunoglobulin (Ig) E and IgG1, inhibiting Th2 differentiation and the production of interleukin (IL)-4 while promoting the differentiation of regulatory T cells. However, the LA-Post group (lactic acid administered after sensitization) reduced only the levels of IgE and IL-4. Additionally, the LA-Pre group demonstrated significant regulation of the abundance of intestinal microbiota, influencing the numbers of Firmicutes, Bacteroidetes, and Lactobacilli in the intestinal tracts. Taken together, the antiallergic activity of lactic acid was examined providing a novel strategy for the prevention and treatment of CMA.

Keywords

cow’s milk allergy; intestinal microbiota; lactic acid; regulatory T cells.

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