2. Academic Validation
  3. Pharmacological activation of SERCA2 reverses ER calcium dysregulation and depression-like behaviors in hyperglycemic mice

Pharmacological activation of SERCA2 reverses ER calcium dysregulation and depression-like behaviors in hyperglycemic mice

  • Sci Rep. 2025 Dec 12. doi: 10.1038/s41598-025-31293-7.
Huiju Lee 1,  Yiseul Han 1,  Ju-Yeon Song 1,  Do Gyeong Kim 1,  Heekyoung Chung 1 2,  Sung Jun Jung 3 4 5,  Hyeon Son 6 7 8
Affiliations

Affiliations

  • 1 Hanyang Biomedical Research Institute, Hanyang University, Seongdong-gu, Seoul, 04763, Korea.
  • 2 Department of Pathology, College of Medicine, Hanyang University, Seongdong-gu, Seoul, 04763, Korea.
  • 3 Hanyang Biomedical Research Institute, Hanyang University, Seongdong-gu, Seoul, 04763, Korea. [email protected].
  • 4 Department of Physiology, College of Medicine, Hanyang University, Seongdong-gu, Seoul, 04763, Korea. [email protected].
  • 5 College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. [email protected].
  • 6 Hanyang Biomedical Research Institute, Hanyang University, Seongdong-gu, Seoul, 04763, Korea. [email protected].
  • 7 Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seongdong-gu, Seoul, 04763, Korea. [email protected].
  • 8 College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. [email protected].
PMID: 41387522 DOI: 10.1038/s41598-025-31293-7
Keywords

CDN1163; Depression; ER stress; Hyperglycemia; SERCA2.

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