2. Academic Validation
  3. Omaciclovir suppresses influenza A virus replication via interaction with viral PA protein

Omaciclovir suppresses influenza A virus replication via interaction with viral PA protein

  • Vet Microbiol. 2026 Jan:312:110843. doi: 10.1016/j.vetmic.2025.110843.
Changjie Lv 1,  Wanxin Wei 2,  Jianmei Wu 3,  Shuang Wang 3,  Guijie Guo 4
Affiliations

Affiliations

  • 1 Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Engineering Research Center for Animal Breeding and Sustainable Production, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • 2 Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • 3 Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
  • 4 Key Laboratory of Animal Pathogen Infection and Immunology of Fujian Province, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Joint Laboratory of Animal Pathogen Prevention and Control of Fujian-Nepal, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Engineering Research Center for Animal Breeding and Sustainable Production, College of Animal Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Electronic address: [email protected].
PMID: 41406559 DOI: 10.1016/j.vetmic.2025.110843
Abstract

Influenza A virus (IAV) is a segmented negative-strand RNA virus that causes seasonal epidemics and occasional pandemics, posing a great threat to the public health. Current vaccines and Antiviral drugs can not completely protect human and Animals from IAV Infection due to high frequency mutations in the viral genome and the emergence of drug-resistant strains, presenting an urgent need to explore new drugs against IAV Infection. Here, we identified that omaciclovir significantly suppressed the replication of IAV. In vitro studies showed that omaciclovir inhibited replication of different IAV subtypes, including H1N1, H3N2 and H9N2. Furthermore, we demonstrated that omaciclovir strikingly attenuated replication of IAV in mice, as evidenced by a lower degree of tissue injury, slower body weight loss, and better survival, than the untreated Animals following IAV Infection. Mechanistically, omaciclovir interacted with viral PA protein, and interfered with the activity of IAV polymerase complexes, thereby limiting the synthesis of viral RNA (vRNA), complementary RNA (cRNA), and messenger RNA (mRNA). Together, these findings characterize the Antiviral property of omaciclovir against IAV in vitro and in vivo, and provide insights into the development of potential antivirals against IAV Infection.

Keywords

Influenza virus; Omaciclovir; PA; Viral polymerase complex.

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  • HY-116174
    99.47%, Herpesvirus Inhibitor
    HSV
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