Translational investigation of tolinapant (ASTX660) in acute myeloid leukemia by integrating clinical, bioinformatic and pharmacological approaches

Affiliations

• 1 Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. [email protected].
• 2 Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, Brazil. [email protected].
• 3 Division of Hematology, Faculdade de Medicina of University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, São Paulo, SP, CEP 05403-000, Brazil. [email protected].
• 4 Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.
• 5 Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
• 6 Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. [email protected].
• 7 Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, Brazil. [email protected].
• 8 Division of Hematology, Faculdade de Medicina of University of São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 155, São Paulo, SP, CEP 05403-000, Brazil. [email protected].