Synthesis and biological evaluation of 1,3,5-triazine and 2-aminopyrimidine scaffolds as chemical probes targeting the 5-HT7-FOXM1 axis in triple-negative breast cancer

Affiliations

• 1 Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, Cracow, 31-155, Poland. Electronic address: [email protected].
• 2 Polish Academy of Sciences, Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Experimental Anticancer Therapy, Wrocław, Poland.
• 3 Polish Academy of Sciences, Hirszfeld Institute of Immunology and Experimental Therapy, Laboratory of Biomedical Chemistry, Wrocław, Poland.
• 4 Department of Organic Chemistry and Technology, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, Cracow, 31-155, Poland.
• 5 Department of Chemical Technology and Environmental Analytics, Faculty of Chemical Engineering and Technology, Cracow University of Technology, 24 Warszawska Street, Cracow, 31-155, Poland.
• 6 Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1A, Chorzów, 41-500, Poland.
• 7 Maj Institute of Pharmacology, Polish Academy of Sciences, Centre for the Development of Novel Pharmacotherapies for CNS Disorders (Cephares), 12 Smętna Street, Cracow, 31-343, Poland.
• 8 University of Bari "Aldo Moro", Department of Pharmacy-Pharmaceutical Sciences, 4 E. Orabona Street, Bari, I-70125, Italy.
• 9 Department of Physical Chemistry, Faculty of Chemistry, Medical University of Gdańsk, 107 Gen. Hallera Alley, Gdańsk, 80-416, Poland.
• 10 Department of Physical Chemistry, Faculty of Chemistry, Medical University of Gdańsk, 107 Gen. Hallera Alley, Gdańsk, 80-416, Poland; Laboratory of Environmental Chemoinformatics, Faculty of Chemistry, University of Gdansk, 63 Wita Stwosza Street, Gdansk, 80-308, Poland.