2. Academic Validation
  3. Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation

Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation

  • Mar Drugs. 2026 Mar 13;24(3):108. doi: 10.3390/md24030108.
Guangli Deng 1,  Wu Ruan 1,  Qun Li 1,  Qingyun Peng 1,  Yunan Liu 1,  Lingbin Lin 1,  Yuan Li 1,  Qianqian Shen 2,  Yangrong Zhao 2,  Junfeng Wang 3,  Yi Chen 2,  Ming-Wei Wang 1
Affiliations

Affiliations

  • 1 Research Center for Deepsea Bioresources, Sanya 572025, China.
  • 2 State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • 3 South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
PMID: 41892967 DOI: 10.3390/md24030108
Abstract

Nine new mycophenolic acid derivatives, penicacids O-W (1-9), two first-time reported natural products (10, 11), and five known compounds (12-16), were isolated from a marine-derived fungus Penicillium senticosum RCDB005 found in a South China Sea sediment sample. Their structures were determined using NMR, HRESIMS, and optical rotatory dispersion (ORD) spectra, electronic circular dichroism (ECD) calculations, X-ray crystallography, and modified Mosher's methods. Eight of these compounds were evaluated for anti-proliferative effects against nine human Cancer cell lines and the IC50 values ranged from nM to μM levels. Compounds 5, 7-9 showed potent inhibition activity against MOLM-13 acute myeloid leukemia cells with IC50 values between 0.13 and 1.13 μM.

Keywords

acute myeloid leukemia; marine-derived Penicillium; modified Mosher’s method; mycophenolic acid derivative; theoretical calculation.

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