2. Academic Validation
  3. The Endocytic Receptor DEC205 Is Expressed by Brain Endothelial Cells and Is Involved in Regulating the Blood-Brain Barrier

The Endocytic Receptor DEC205 Is Expressed by Brain Endothelial Cells and Is Involved in Regulating the Blood-Brain Barrier

  • Cells. 2026 May 12;15(10):882. doi: 10.3390/cells15100882.
Sonali Singh 1,  Sabine Ring 1,  Xuan Lei 1,  Mohamad Alabdullah 1,  Yutaka Inaba 2,  Alexander Enk 1,  Karsten Mahnke 1
Affiliations

Affiliations

  • 1 Department of Dermatology, University Hospital Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany.
  • 2 Department of Dermatology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-0012, Japan.
PMID: 42193892 DOI: 10.3390/cells15100882
Abstract

The surface receptor DEC205 (alias CD205, NLDC-145, Ly75) has long been a marker for murine dendritic cells and Langerhans cells and functions as receptor to facilitate antigen uptake. We revisited the tissue expression pattern of DEC205 in mice and revealed expression by endothelial cells (ECs) in the central nervous system. Using the murine brain-derived EC line bEnd.3, we could show that DEC205 serves as an endocytic receptor that directs potential ligands to lysosomal compartments. As for its function in ECs, upon engagement by anti-DEC205 antibodies, DEC205 seems to guide Claudin 5, a component of endothelial junctions, away from the surface of ECs to a LAMP-1+, degradative compartment. This opens endothelial junctions, eventually allowing leukocytes to migrate from blood to tissue sites. In aggregate, by regulating the blood-brain barrier, DEC205 in ECs may contribute to the regulation of inflammatory processes in the central nervous system.

Keywords

DEC205; blood–brain barrier; endothelial cells.

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