2. Academic Validation
  3. Anxiolytic-like properties of fominoben

Anxiolytic-like properties of fominoben

  • Eur J Pharmacol. 1984 Jan 27;97(3-4):277-81. doi: 10.1016/0014-2999(84)90460-6.
J N Crawley,  L K Blumstein,  F Baldino Jr
PMID: 6142823 DOI: 10.1016/0014-2999(84)90460-6
Abstract

Fominoben, a centrally acting antitussive, has been shown recently to bind to the brain benzodiazepine binding site and to antagonize pentylenetetrazol-induced seizures. The present study reports the ability of fominoben to produce anti-anxiety effects analogous to diazepam in a mouse exploratory model for anxiolytics. This action of fominoben was blocked by Ro15-1788, a benzodiazepine receptor antagonist, implicating a brain benzodiazepine binding site in this anxiolytic action of fominoben.

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