2. Academic Validation
  3. In vitro activity of 2-alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva

In vitro activity of 2-alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva

  • J Med Chem. 1981 Mar;24(3):295-9. doi: 10.1021/jm00135a011.
P Boehm,  K Cooper,  A T Hudson,  J P Elphick,  N McHardy
PMID: 6790703 DOI: 10.1021/jm00135a011
Abstract

A variety of naphthoquinones have veen prepared and evaluated in vitro against the causative agent of the cattle disease East Coast Fever-Theileria parva Infection. It is concluded from structure-activity studies that a 2-hydroxyl moiety es essential for high activity. The most active compounds tested were 2-hydroxy-3-alkyl-1,4-naphthoquinones in which the alkyl moiety was cyclohexyl, cyclohexylcyclohexyl, tridecyl, or tetradecyl.

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