2. Academic Validation
  3. Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemia

Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemia

  • Br J Pharmacol. 1981 Sep;74(1):12-4. doi: 10.1111/j.1476-5381.1981.tb09949.x.
O Fagbemi,  J R Parratt
PMID: 7272595 DOI: 10.1111/j.1476-5381.1981.tb09949.x
Abstract

The oral administration to rats of the calcium antagonists nifedipine, nisoldipine and niludipine (3 mg/kg, 1-1.25 h before acute coronary ligation) greatly reduced the duration of ventricular tachycardia and fibrillation (VF) occurring in the first 30 min post-ligation period. The duration of VF was especially reduced (by 74-92%). None of the Animals so treated died compared with a 40% mortality in the controls.

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