2. Academic Validation
  3. Cathepsin E in antigen-presenting Langerhans and interdigitating reticulum cells. Its possible role in antigen processing

Cathepsin E in antigen-presenting Langerhans and interdigitating reticulum cells. Its possible role in antigen processing

  • Eur J Histochem. 1993;37(1):19-26.
E Solcia 1,  M Paulli,  E Silini,  R Fiocca,  G Finzi,  S Kindl,  E Boveri,  F Bosi,  M Cornaggia,  C Capella
Affiliations

Affiliation

  • 1 Dipartimento di Patologia Umana ed Ereditaria, I Facoltà di Medicina e Chirurgia, Università di Pavia ed I.R.C.C.S. Policlinico S. Matteo, Italy.
PMID: 7682863
Abstract

A specific rabbit anti-human Cathepsin E serum detected this aspartic proteinase in Langerhans cells of the skin, in interdigitating reticulum cells of lymph nodes and spleen and in histiocytosis X cells, but not in macrophages. Immunoblotting of tissue extracts confirmed the presence of Cathepsin E in skin and lymph nodes. Electron immunocytochemistry with the protein A gold technique localized Cathepsin E in the endoplasmic reticulum and in endosomal vesicles of both interdigitating and Langerhans cells, likely involving Birbeck bodies. A role of endosomal Cathepsin E in antigen processing is suggested.

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