2. Academic Validation
  3. Antiplatelet constituents of formosan Rubia akane

Antiplatelet constituents of formosan Rubia akane

  • J Nat Prod. 1994 Feb;57(2):313-6. doi: 10.1021/np50104a020.
M I Chung 1,  S J Jou,  T H Cheng,  C N Lin,  F N Ko,  C M Teng
Affiliations

Affiliation

  • 1 Natural Products Research Center, Kaohsiung Medical College, Taiwan, Republic of China.
PMID: 8176404 DOI: 10.1021/np50104a020
Abstract

A known steroid, in addition to triterpenoids, Anthraquinones, naphthalenes and a new anthraquinone glycoside, xanthopurpurin 3-O-beta-D-glucoside, were isolated from the roots of Rubia akane grown in Taiwan. Mollugin, a naphthohydroquinone, showed strong inhibition of arachidonic acid (AA)-induced and collagen-induced platelet aggregation. In contrast, 2-methyl-1,3,6-trihydroxyl-9,10-anthraquinone, xanthopurpurin 3-O-beta-D-glucoside, and xanthopurpurin showed mainly strong inhibition of collagen-induced platelet aggregation.

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