2. Academic Validation
  3. Puqiedinone, a novel 5 alpha-cevanine alkaloid from the bulbs of Fritillaria puqiensis, an antitussive traditional Chinese medicine

Puqiedinone, a novel 5 alpha-cevanine alkaloid from the bulbs of Fritillaria puqiensis, an antitussive traditional Chinese medicine

  • J Nat Prod. 1995 Nov;58(11):1662-7. doi: 10.1021/np50125a003.
G Lin 1,  Y P Ho,  P Li,  X G Li
Affiliations

Affiliation

  • 1 Department of Pharmacology, Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
PMID: 8594143 DOI: 10.1021/np50125a003
Abstract

A novel 5 alpha-cevanine alkaloid, puqiedinone [1], was isolated from the bulbs of Fritillaria puqiensis, a traditional Chinese medicine used widely for its antitussive and expectorant properties. The structure of 1 was assigned as (20R,22S,25R)-20-deoxy-5 alpha-cevanine-3 beta-ol-6-one based on spectral analysis and comparison with the structures of related known compounds. Puqietinone [2] was also identified from the same herbal plant and the structure was revised as (22R,25S)-N-methyl-22,26-epiminocholest-3 beta-ol-6-one based on spectroscopic and X-ray crystallographic methods.

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