2. Academic Validation
  3. Identification of a major co-receptor for primary isolates of HIV-1

Identification of a major co-receptor for primary isolates of HIV-1

  • Nature. 1996 Jun 20;381(6584):661-6. doi: 10.1038/381661a0.
H Deng 1,  R Liu,  W Ellmeier,  S Choe,  D Unutmaz,  M Burkhart,  P Di Marzio,  S Marmon,  R E Sutton,  C M Hill,  C B Davis,  S C Peiper,  T J Schall,  D R Littman,  N R Landau
Affiliations

Affiliation

  • 1 Skirball Institute for BioMolecular Medicine, New York University Medical Center, 10016, USA.
PMID: 8649511 DOI: 10.1038/381661a0
Abstract

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for Infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the beta-chemokines RANTES, MIP-1alpha and MIP-1beta.

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