2. Academic Validation
  3. Coriadienin, the first annonaceous acetogenin with two double bonds isolated from Annona coriaceae

Coriadienin, the first annonaceous acetogenin with two double bonds isolated from Annona coriaceae

  • J Nat Prod. 1996 May;59(5):528-30. doi: 10.1021/np960079e.
E L Meneses da Silva 1,  F Roblot,  J Mahuteau,  A Cavé
Affiliations

Affiliation

  • 1 Laboratoire de Pharmacognosie et Service de RMN, Faculté de Pharmacie, Châtenay-Malabry, France.
PMID: 8778244 DOI: 10.1021/np960079e
Abstract

A new Annonaceous acetogenin, coriadienin (1), has been isolated from the roots of Annona coriacea Mart. (Annonaceae). This structure is the first reported acetogenin containing two double bonds. Compound 1 showed potent cytotoxicity against VERO and KB cell lines. Compound 1 appears to play an important role in the biosynthetic pathway of mono- and bis-THF acetogenins, and it is proposed as a biogenetic precursor of coriacin. A known cytotoxic acetogenin, gigantetronenin, was also isolated from this plant.

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