2. Academic Validation
  3. Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23

Identification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23

  • Genome Res. 1997 Jan;7(1):71-5. doi: 10.1101/gr.7.1.71.
P J Byrd,  T Stankovic,  C M McConville,  A D Smith,  P R Cooper,  A M Taylor
PMID: 9037604 DOI: 10.1101/gr.7.1.71
Abstract

We have localized the human homolog of the rabbit vasopressin-activated calcium-mobilizing receptor VACM-1 to a region close to the gene for ataxia telangiectasia ATM on chromosome 11q22-23. We have determined the complete amino acid sequence of the human Hs-VACM-1 protein, which is 780 Amino acids long. The human and rabbit sequences are highly conserved, differing at only seven Amino acids. Northern analysis of the human gene showed expression in a wide range of human tissues. The Hs-VACM-1 gene has homology with the Caenorhabditis elegans gene Ce-cul-5, a member of a family of cullin genes that are involved in cell cycle regulation and that might, when mutated, contribute to tumor progression.

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