2. Academic Validation
  3. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

  • Cell. 1997 Apr 18;89(2):309-19. doi: 10.1016/s0092-8674(00)80209-3.
W S Simonet 1,  D L Lacey,  C R Dunstan,  M Kelley,  M S Chang,  R Lüthy,  H Q Nguyen,  S Wooden,  L Bennett,  T Boone,  G Shimamoto,  M DeRose,  R Elliott,  A Colombero,  H L Tan,  G Trail,  J Sullivan,  E Davy,  N Bucay,  L Renshaw-Gegg,  T M Hughes,  D Hill,  W Pattison,  P Campbell,  S Sander,  G Van,  J Tarpley,  P Derby,  R Lee,  W J Boyle
Affiliations

Affiliation

  • 1 Department of Molecular Genetics, Amgen Inc., Thousand Oaks, California 91320, USA.
PMID: 9108485 DOI: 10.1016/s0092-8674(00)80209-3
Abstract

A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF Receptor Superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation. These same effects are observed upon administration of recombinant OPG into normal mice. In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG. Furthermore, OPG blocks ovariectomy-associated bone loss in rats. These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.

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