2. Academic Validation
  3. Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

Limonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emetica

  • J Nat Prod. 1998 Feb;61(2):179-84. doi: 10.1021/np9701687.
A A Gunatilaka 1,  V da S Bolzani,  E Dagne,  G A Hofmann,  R K Johnson,  F L McCabe,  M R Mattern,  D G Kingston
Affiliations

Affiliation

  • 1 Department of Chemistry, Virginia Polytechnic Institute, Blacksburg, USA.
PMID: 9514005 DOI: 10.1021/np9701687
Abstract

Bioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5), and Tr-B (7) and the novel seco-A protolimonoid 8. Of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, 13C NMR spectral assignments, and biological activities of these compounds are reported.

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