2. Academic Validation
  3. Anti-platelet aggregation constituents from Formosan Toddalia asiatica

Anti-platelet aggregation constituents from Formosan Toddalia asiatica

  • Phytochemistry. 1998 Aug;48(8):1377-82. doi: 10.1016/s0031-9422(97)00678-x.
I L Tsai 1,  M F Wun,  C M Teng,  T Ishikawa,  I S Chen
Affiliations

Affiliation

  • 1 Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, R.O.C.
PMID: 9720317 DOI: 10.1016/s0031-9422(97)00678-x
Abstract

Examination on the wood of Formosan Toddalia asiatica led to the isolation of 30 compounds, including Coumarins, Alkaloids, a benzoquinone and an amine. Among the isolates, (+/-)-toddanin and (-)-isocoreximine are new compounds, while cyclohexylamine was isolated for the first time from nature. The structures of the compounds were elucidated from spectroscopic data and chemical evidence. Bioassay-guided fractionation led to the isolation of seven compounds showing strong anti-platelet aggregation activity in vitro.

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