2. Academic Validation
  3. Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice

Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice

  • Eur J Pharmacol. 1998 Oct 16;359(1):55-8. doi: 10.1016/s0014-2999(98)00648-7.
E M Urbanska 1,  P Blaszczak,  T Saran,  Z Kleinrok,  W A Turski
Affiliations

Affiliation

  • 1 Department of Pharmacology and Toxicology, Medical University School, Lublin, Poland. [email protected]
PMID: 9831293 DOI: 10.1016/s0014-2999(98)00648-7
Abstract

3-Nitropropionic acid, a potent inhibitor of succinate dehydrogenase which thus compromises cellular energy metabolism, evoked convulsions in mice in a dose-dependent manner. CD50 for clonic seizures was 158.5 (144.1-174.3) mg/kg. Tonic seizures were not observed. Broad-spectrum anticonvulsants, namely diazepam, phenobarbital and valproate, prevented the occurrence of 3-nitropropionic acid-induced seizures with ED50 of 4.9 (3.1-7.6), 33.1 (17.9-61.0) and 389.7 (351.2-432.3) mg/kg, respectively. Diphenylhydantoin-like drugs (diphenylhydantoin, and carbamazepine), anti-absence drugs (trimethadione and ethosuximide) and acetazolamide were ineffective. The characteristics of 3-nitropropionic acid-induced seizures resembled those of convulsions evoked by another mitochondrial toxin, aminooxyacetic acid.

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