2. Academic Validation
  3. New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells

New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells

  • Bioorg Med Chem Lett. 1998 Jan 20;8(2):189-94. doi: 10.1016/s0960-894x(97)10218-9.
I Ojima 1,  P Y Bounaud,  C Takeuchi,  P Pera,  R J Bernacki
Affiliations

Affiliation

  • 1 Department of Chemistry, State University of New York at Stony Brook 11794-3400, USA.
PMID: 9871652 DOI: 10.1016/s0960-894x(97)10218-9
Abstract

New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast Cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.

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