2. Academic Validation
  3. Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors

Sulfonamide derivatives of benzylamine block cholesterol biosynthesis in HepG2 cells: a new type of potent squalene epoxidase inhibitors

  • Bioorg Med Chem Lett. 1998 Jun 2;8(11):1337-42. doi: 10.1016/s0960-894x(98)00213-3.
J P Gotteland 1,  C Loubat,  B Planty,  D Junquéro,  A Delhon,  S Halazy
Affiliations

Affiliation

  • 1 Medicinal Chemistry Division, Centre de Recherche Pierre Fabre, Castres, France. [email protected]
PMID: 9871762 DOI: 10.1016/s0960-894x(98)00213-3
Abstract

Sulfonamide derivatives of ene-yne benzylamine 1 have been prepared and identified as a new class of potent SE inhibitors having demonstrated activity in HepG2 cells as Cholesterol biosynthesis inhibitors.

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