2. Academic Validation
  3. Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine

Conformationally constrained NO synthase inhibitors: rigid analogs of L-N-iminoethylornithine

  • Bioorg Med Chem Lett. 1998 Nov 3;8(21):2961-6. doi: 10.1016/S0960-894X(98)00532-0.
J Eustache 1,  A Grob,  C Lam,  O Sellier,  G Schulz
Affiliations

Affiliation

  • 1 Laboratoire de Synthèse Organique et Chimie Microbienne associé au CNRS, Université de Haute-Alsace, Ecole Nationale Supérieure de Chimie de Mulhouse, France. [email protected]
PMID: 9873655 DOI: 10.1016/S0960-894X(98)00532-0
Abstract

The synthesis of eight rigid analogs of L-N-iminoethylornithine (L-NIO) is described. The compounds have been evaluated for their inhibition of inducible nitric oxide synthase. Preliminary structure-activity relationships are discussed.

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