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Results for "

protac-gsk-3

" in MedChemExpress (MCE) Product Catalog:

6

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1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149845
    PROTAC GSK-3β Degrader-1

    		PROTACs GSK-3 Neurological Disease
    PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets GSK-3β degradation with an IC50 value of 833 nM. PROTAC GSK-3β Degrader-1 contains SB-216763 (a GSK-3β inhibitor), a PEG linker and a CRBN (E3 ligase liand). PROTAC GSK-3β Degrader-1 reduces the neurotoxicity induced by Aβ25-35 peptide and CuSO4. PROTAC GSK-3β Degrader-1 can be used to research in Alzheimer's disease .
    PROTAC GSK-3β Degrader-1
  • HY-185634
    PROTAC GSK3 degrader-1

    		PROTACs GSK-3 Tau Protein Neurological Disease
    PROTAC GSK3 degrader-1 is a potent, blood-brain barrier-permeable GSK3 PROTAC degrader, with a DC50 of 1.4 nM against GSK3β. PROTAC GSK3 degrader-1 exerts equally potent degradation activity against both GSK3α and GSK3β. It inhibits the phosphorylation of CRMP2, PRKAA1 and Tau, and stabilizes β-catenin. PROTAC GSK3 degrader-1 can be used in the research of Alzheimer's disease and Parkinson's disease .
    PROTAC GSK3 degrader-1
  • HY-185635
    GSK3 ligand-1

    		Ligands for Target Protein for PROTAC GSK-3
    GSK3 ligand-1 (GSK3 binder reagent 2) is a GSK3 ligand that can be used for the synthesis of PROTACs, such as PROTAC GSK3 degrader-1 (HY-185634) .
    GSK3 ligand-1
  • HY-W1137162
    CRBN ligand-904

    		Ligands for E3 Ligase Others
    CRBN ligand-904 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), which is used to recruit cereblon protein. CRBN ligand-904 can be linked to a target protein ligand via a linker to form a PROTAC, such as PROTAC GSK3 degrader-1 (HY-185634) .
    CRBN ligand-904
  • HY-W068828
    1,4-Butanediol bis(3-aminopropyl) ether

    4,9-Dioxa-1,12-dodecanediamine

    		 PROTAC Linkers Others
    1,4-Butanediol bis(3-aminopropyl) ether (4,9-Dioxa-1,12-dodecanediamine) is a PROTAC linker. Pent-4-yn-1-ol can be used to synthesize PROTAC molecules (e.g., PROTAC GSK-3β Degrader-1 (HY-149845)) .
    1,4-Butanediol bis(3-aminopropyl) ether
  • HY-182978
    Pomalidomide-C3-O-C4-O-C3-NH2

    		E3 Ligase Ligand-Linker Conjugates Others
    Pomalidomide-C3-O-C4-O-C3-NH2 is an E3 ligase ligand-linker conjugate that contains Pomalidomide (HY-10984). Pomalidomide-C3-O-C4-O-C3-NH2 can be used for the synthesis of PROTACs targeting glycogen synthase kinase 3β (GSK-3β), such as PROTAC GSK-3β Degrader-1 (HY-149845) .
    Pomalidomide-C3-O-C4-O-C3-NH2

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