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Cat. No.: HY-182978

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Pomalidomide-C3-O-C4-O-C3-NH2

Pomalidomide-C3-O-C4-O-C3-NH2 is an E3 ligase ligand-linker conjugate that contains Pomalidomide (HY-10984). Pomalidomide-C3-O-C4-O-C3-NH2 can be used for the synthesis of PROTACs targeting glycogen synthase kinase 3β (GSK-3β), such as PROTAC GSK-3β Degrader-1 (HY-149845).

For research use only. We do not sell to patients.

CAS No.: 2138439-13-9
Formula: C₂₃H₃₂N₄O₆
Molecular Weight:460.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pomalidomide-C3-O-C4-O-C3-NH2 Chemical Structure

CAS No.: 2138439-13-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

Pomalidomide-C3-O-C4-O-C3-NH2 can be used for the synthesis of PROTAC GSK-3β Degrader-1. PROTAC GSK-3β Degrader-1 (compound 1) is a degrader targets GSK-3β degradation with an IC₅₀ value of 833 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2138439-13-9
Molecular Weight 460.52
Formula C₂₃H₃₂N₄O₆
SMILES

NCCCOCCCCOCCCNC1=C(C2=CC=C1)C(N(C2=O)C3CCC(NC3=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Guardigni M, et al. PROTAC-Induced Glycogen Synthase Kinase 3β Degradation as a Potential Therapeutic Strategy for Alzheimer's Disease. ACS Chem Neurosci. 2023;14(11):1963-1970. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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Pomalidomide-C3-O-C4-O-C3-NH2

All E3 Ligase Ligand-Linker Conjugates Isoforms