Quinacrine mustard dihydrochloride

Name: Quinacrine mustard dihydrochloride
Brand: MedChemExpress
SKU: HY-W127705
Rating: 4.5 (1 reviews)

製品番号: HY-W127705 純度: 95.25%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Quinacrine mustard dihydrochloride 構造式

CAS 番号 : 4213-45-0

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 103	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 103	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$86	在庫あり	Estimated Time of Arrival: December 31
10 mg	$140	在庫あり	Estimated Time of Arrival: December 31
25 mg	$309	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

顧客検証

•Pigment Cell Melanoma Res. 2025 Sep;38(5):e70048. [Abstract]

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純度とドキュメンテーション
参考文献
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製品説明

体外実験

Quinacrine mustard dihydrochloride (5 μg/mL) can be used for the DNA strain of plant, animal, or human chromosomes^[1].
Quinacrine mustard dihydrochloride (28 μM) increases the number of mutants that appeared after an exposure of bacteria^[2].
quinacrine mustard dihydrochloride (0.2 μM; 4h) induces cell cycle arrest at G2+M-phase in HL-60 cells^[3].
Caffeine (5 mM) prevents the cytotoxic action of quinacrine mustard dihydrochloride (0.2 μM; 4h) in HL-60 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[3]

Cell Line:	HL-60 cells
Concentration:	0.2 µM
Incubation Time:	4 h
Result:	Induced cell cycle arrest at G2+M-phase with the accumulation of cells in this compartment by 50%.

分子量

541.77

分子式

C₂₃H₃₀Cl₅N₃O

CAS 番号

4213-45-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(CCCN(CCCl)CCCl)N=C1C2=C(C=C(C=C2)Cl)NC3=C1C=C(C=C3)OC.Cl.Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶剤 & 溶解度

体外:

DMSO : 25 mg/mL (46.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 6.25 mg/mL (11.54 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8458 mL	9.2290 mL	18.4580 mL
5 mM	0.3692 mL	1.8458 mL	3.6916 mL
10 mM	0.1846 mL	0.9229 mL	1.8458 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 95.25%

Select Batch:

データシート (276 KB) SDS (645 KB)

COA (252 KB) HNMR (589 KB) RP-HPLC (267 KB) MS (68 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Caspersson T, et al. Fluorescent labeling of chromosomal DNA: superiority of quinacrine mustard to quinacrine. Science. 1970 Nov 13;170(3959):762. [Content Brief]

[2]. Piosik J, et al. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutat Res. 2003 Sep 29;530(1-2):47-57. [Content Brief]

[3]. Kapuscinski J, et al. The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine. Biochem Pharmacol. 2002 Feb 15;63(4):625-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.8458 mL	9.2290 mL	18.4580 mL	46.1450 mL
	5 mM	0.3692 mL	1.8458 mL	3.6916 mL	9.2290 mL
	10 mM	0.1846 mL	0.9229 mL	1.8458 mL	4.6145 mL
DMSO	15 mM	0.1231 mL	0.6153 mL	1.2305 mL	3.0763 mL
	20 mM	0.0923 mL	0.4615 mL	0.9229 mL	2.3073 mL
	25 mM	0.0738 mL	0.3692 mL	0.7383 mL	1.8458 mL
	30 mM	0.0615 mL	0.3076 mL	0.6153 mL	1.5382 mL
	40 mM	0.0461 mL	0.2307 mL	0.4615 mL	1.1536 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.