Quinacrine mustard dihydrochloride

Name: Quinacrine mustard dihydrochloride
Brand: MedChemExpress
SKU: HY-W127705
Rating: 4.5 (1 reviews)

Art. -Nr.: HY-W127705 Reinheit: 95.25%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes.

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Quinacrine mustard dihydrochloride Chemische Struktur

CAS. Nr. : 4213-45-0

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Angebot einholen
100 mg	Angebot einholen

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Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Quinacrine mustard dihydrochloride

•Pigment Cell Melanoma Res. 2025 Sep;38(5):e70048. [Abstract]

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

In Vitro

Quinacrine mustard dihydrochloride (5 μg/mL) can be used for the DNA strain of plant, animal, or human chromosomes^[1].
Quinacrine mustard dihydrochloride (28 μM) increases the number of mutants that appeared after an exposure of bacteria^[2].
quinacrine mustard dihydrochloride (0.2 μM; 4h) induces cell cycle arrest at G2+M-phase in HL-60 cells^[3].
Caffeine (5 mM) prevents the cytotoxic action of quinacrine mustard dihydrochloride (0.2 μM; 4h) in HL-60 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[3]

Cell Line:	HL-60 cells
Concentration:	0.2 µM
Incubation Time:	4 h
Result:	Induced cell cycle arrest at G2+M-phase with the accumulation of cells in this compartment by 50%.

Molekulargewicht

541.77

Formel

C₂₃H₃₀Cl₅N₃O

CAS. Nr.

4213-45-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(CCCN(CCCl)CCCl)N=C1C2=C(C=C(C=C2)Cl)NC3=C1C=C(C=C3)OC.Cl.Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (46.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 6.25 mg/mL (11.54 mM; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8458 mL	9.2290 mL	18.4580 mL
5 mM	0.3692 mL	1.8458 mL	3.6916 mL
10 mM	0.1846 mL	0.9229 mL	1.8458 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 95.25%

Select Batch:

Data Sheet (276 KB) SDS (645 KB)

COA (252 KB) HNMR (589 KB) RP-HPLC (267 KB) MS (68 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Caspersson T, et al. Fluorescent labeling of chromosomal DNA: superiority of quinacrine mustard to quinacrine. Science. 1970 Nov 13;170(3959):762. [Content Brief]

[2]. Piosik J, et al. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutat Res. 2003 Sep 29;530(1-2):47-57. [Content Brief]

[3]. Kapuscinski J, et al. The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine. Biochem Pharmacol. 2002 Feb 15;63(4):625-34. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.8458 mL	9.2290 mL	18.4580 mL	46.1450 mL
	5 mM	0.3692 mL	1.8458 mL	3.6916 mL	9.2290 mL
	10 mM	0.1846 mL	0.9229 mL	1.8458 mL	4.6145 mL
DMSO	15 mM	0.1231 mL	0.6153 mL	1.2305 mL	3.0763 mL
	20 mM	0.0923 mL	0.4615 mL	0.9229 mL	2.3073 mL
	25 mM	0.0738 mL	0.3692 mL	0.7383 mL	1.8458 mL
	30 mM	0.0615 mL	0.3076 mL	0.6153 mL	1.5382 mL
	40 mM	0.0461 mL	0.2307 mL	0.4615 mL	1.1536 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.