2. Protein Tyrosine Kinase/RTK
  3. VEGFR
  4. Ramucirumab

Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab is also an angiogenesis inhibitor.

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Ramucirumab Chemical Structure

Ramucirumab Chemical Structure

CAS No. : 947687-13-0

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Based on 2 publication(s) in Google Scholar

Ramucirumab Related Antibodies

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Description

Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors. Ramucirumab is a recombinant human immunoglobulin G1 monoclonal antibody that binds to the extracellular binding domain of VEGFR-2 and prevents the binding of VEGFR ligands: VEGF-A, VEGF-C, and VEGF-D. Ramucirumab is also an angiogenesis inhibitor[1][2].

IC50 & Target[1][2]

VEGFR-2

 

In Vitro

Ramucirumab (10 μg/mL) impedes both VEGF- and tumor-driven cord formation[3].
? Ramucirumab does not cross react with mouse VEGFR2[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ramucirumab Related Antibodies
Clinical Trial
Molecular Weight

143609.63

Formula

C6374H9864N1692O1996S46
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Ramucirumab]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.40%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Ramucirumab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ramucirumab947687-13-0VEGFRVascular endothelial growth factor receptorangiogenesis inhibitorNSCLCnon–small-cell lung cancergastric cancerInhibitorinhibitorinhibit

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