1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Peptide Hormone & Neuropeptides
  4. AGRP Protein, Mouse (131a.a, HEK293, Fc)

AGRP Protein, Mouse (131a.a, HEK293, Fc)

Cat. No.: HY-P75525
Handling Instructions

The AGRP protein is critical for body weight homeostasis and regulates feeding behavior through the central melanocortin system. As an antagonist of alpha melanocyte-stimulating hormone, AGRP inhibits cAMP production through melanocortin receptors in the hypothalamus and adrenal glands. AGRP Protein, Mouse (131a.a, HEK293, Fc) is the recombinant mouse-derived AGRP protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AGRP Protein, Mouse (131a.a, HEK293, Fc) is 131 a.a., with molecular weight of ~41 kDa.

For research use only. We do not sell to patients.

Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

The AGRP protein is critical for body weight homeostasis and regulates feeding behavior through the central melanocortin system. As an antagonist of alpha melanocyte-stimulating hormone, AGRP inhibits cAMP production through melanocortin receptors in the hypothalamus and adrenal glands. AGRP Protein, Mouse (131a.a, HEK293, Fc) is the recombinant mouse-derived AGRP protein, expressed by HEK293 , with C-hFc labeled tag. The total length of AGRP Protein, Mouse (131a.a, HEK293, Fc) is 131 a.a., with molecular weight of ~41 kDa.

Background

The AGRP protein plays a crucial role in maintaining weight homeostasis. It is involved in the regulation of feeding behavior through the central melanocortin system. AGRP acts as an antagonist of alpha melanocyte-stimulating hormone by inhibiting cAMP production mediated by the stimulation of melanocortin receptors in the hypothalamus and adrenal gland. It exhibits minimal activity with MC5R but functions as an inverse agonist for MC3R and MC4R, effectively suppressing their constitutive activity. AGRP also promotes the endocytosis of MC3R and MC4R in an arrestin-dependent manner. Furthermore, it interacts with melanocortin receptors MC3R, MC4R, and MC5R.

Species

Mouse

Source

HEK293

Tag

C-hFc

Accession

P56473 (M1-T131)

Gene ID

11604  [NCBI]

Molecular Construction
N-term
AGRP (M1-T131)
Accession # P56473
hFc
C-term
Synonyms
Agouti-related protein; AGRP; AGRT; ART
Molecular Weight

Approximately 41 kDa

Purity

Greater than 85% as determined by reducing SDS-PAGE

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

AGRP Protein, Mouse (131a.a, HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AGRP Protein, Mouse (131a.a, HEK293, Fc)
Cat. No.:
HY-P75525
Quantity:
MCE Japan Authorized Agent: