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  5. AGRP Protein, Rhesus Macaque (HEK293, Fc)

AGRP Protein, Rhesus Macaque (HEK293, Fc)

Cat. No.: HY-P75566
Handling Instructions

AGRP protein is an alpha-melanocyte stimulating hormone antagonist that regulates feeding behavior through the central melanocortin system to maintain body weight balance. AGRP inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal glands. AGRP can act as an inhibitor of MC3R and MC4R. AGRP Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived AGRP protein, expressed by HEK293 , with N-mFc labeled tag. The total length of AGRP Protein, Rhesus Macaque (HEK293, Fc) is 50 a.a., with molecular weight of ~32.3 kDa.

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Description

AGRP protein is an alpha-melanocyte stimulating hormone antagonist that regulates feeding behavior through the central melanocortin system to maintain body weight balance. AGRP inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal glands. AGRP can act as an inhibitor of MC3R and MC4R. AGRP Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived AGRP protein, expressed by HEK293 , with N-mFc labeled tag. The total length of AGRP Protein, Rhesus Macaque (HEK293, Fc) is 50 a.a., with molecular weight of ~32.3 kDa.
Background

AGRP protein plays a crucial role in body weight balance and regulates feeding behavior through the central melanocortin system. AGRP is an alpha-melanocyte stimulating hormone antagonist that inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal glands. AGRP can act as an inverse agonist of MC3R and MC4R, inhibiting their constituent activity. AGRP promotes endocytosis of MC3R and MC4R in an inhibitory dependent manner[1][2][3].
Species

Rhesus Macaque
Source

HEK293
Tag

N-mFc
Accession

XP_001091740 (S83-T132)
Gene ID

698479  [NCBI]
Molecular Construction
N-term
mFc
AGRP (S83-T132)
Accession # XP_001091740
C-term
Synonyms
Agouti-related protein; AGRP; AGRT; ART
Molecular Weight

Approximately 32.3 kDa
Purity

Greater than 90% as determined by reducing SDS-PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

AGRP Protein, Rhesus Macaque (HEK293, Fc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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