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  2. Cytokines and Growth Factors
  3. Angiopoietins
  4. ANG-1
  5. Angiopoietin-1 Protein, Mouse (HEK293, His)

Angiopoietin-1 Protein, Mouse (HEK293, His)

Cat. No.: HY-P74412
COA Handling Instructions

Angiopoietin-1 (ANGPT1) is a secreted glycoprotein that belongs to the angiopoietin family. It actively regulates blood vessel formation and stabilization, playing a pivotal role in vascular development. ANGPT1 also influences skeletal myoblasts and orchestrates the vascular response to tissue injury. Its broad expression in various tissues highlights its significance in diverse physiological contexts. Angiopoietin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag. The total length of Angiopoietin-1 Protein, Mouse (HEK293, His) is 222 a.a., with molecular weight of ~28 kDa.

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Description

Angiopoietin-1 (ANGPT1) is a secreted glycoprotein that belongs to the angiopoietin family. It actively regulates blood vessel formation and stabilization, playing a pivotal role in vascular development. ANGPT1 also influences skeletal myoblasts and orchestrates the vascular response to tissue injury. Its broad expression in various tissues highlights its significance in diverse physiological contexts. Angiopoietin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Angiopoietin-1 protein, expressed by HEK293 , with N-His labeled tag. The total length of Angiopoietin-1 Protein, Mouse (HEK293, His) is 222 a.a., with molecular weight of ~28 kDa.

Background

Angiopoietin-1 (ANGPT1) encodes a secreted glycoprotein within the angiopoietin family of vascular growth factors. As a crucial ligand in the vascular tyrosine kinase signaling pathway, this protein actively regulates the formation and stabilization of blood vessels, demonstrating its pivotal role in vascular development. Beyond its vascular functions, ANGPT1 operates in striated muscles, influencing the proliferation, migration, and differentiation of skeletal myoblasts. Moreover, ANGPT1 plays a vital role in orchestrating the vascular response to tissue injury. The gene exhibits alternative splicing, resulting in multiple transcript variants. Its broad expression across various tissues, including the heart, lung, and other anatomical sites, underscores the significance of ANGPT1 in diverse physiological contexts.

Species

Mouse

Source

HEK293

Tag

N-His

Accession

NP_033770.2 (R277-F498)

Gene ID

11600  [NCBI]

Molecular Construction
N-term
His
Angiopoietin-1 (R277-F498)
Accession # NP_033770.2
C-term
Synonyms
AGP1; AGPT; ANG-1; Angiopoietin-1; ANGPT1
Molecular Weight

Approximately 28 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Solution.

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

Angiopoietin-1 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Angiopoietin-1 Protein, Mouse (HEK293, His)
Cat. No.:
HY-P74412
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