1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Angiopoietins
  4. Angiopoietin Like 4
  5. ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His)

ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His)

Cat. No.: HY-P78237
Handling Instructions

ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is 243 a.a., with molecular weight of 35-50 kDa.

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Description

ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is 243 a.a., with molecular weight of 35-50 kDa.

Background

ANGPTL4/Angiopoietin-related 4 Protein assumes a pivotal role in the intricate regulation of lipid metabolism by mediating the inactivation of lipoprotein lipase (LPL), thereby contributing to the control of triglyceride clearance from the bloodstream. Beyond its involvement in lipid metabolism, ANGPTL4 may also play a crucial part in regulating glucose homeostasis and insulin sensitivity. Moreover, it exerts inhibitory effects on endothelial cells by impeding proliferation, migration, and tubule formation, ultimately reducing vascular leakage. In vitro studies demonstrate that ANGPTL4, when expressed heterologously, hampers endothelial cell adhesion to the extracellular matrix (ECM), inhibits the reorganization of the actin cytoskeleton, and disrupts the formation of actin stress fibers and focal adhesions. Additionally, ANGPTL4's cleaved form exhibits higher activity in LPL inactivation compared to the uncleaved protein, further emphasizing its multifaceted role in lipid homeostasis and endothelial cell function. Depending on the context, ANGPTL4 may also modulate tumor-related angiogenesis, underscoring its contextual influence on diverse physiological processes.

Species

Mouse

Source

HEK293

Tag

N-His

Accession

Q9Z1P8 (R168-S410)

Gene ID

57875  [NCBI]

Molecular Construction
N-term
His
ANGPTL4 (R168-S410)
Accession # Q9Z1P8
C-term
Synonyms
ANGPTL4; ARP4; FIAF; HFARP; Angiopoietin like 4; NGPTL2; NL2; PGAR; pp1158; ANG-3; ANG4; AGP4; ANG3; ANG-3; ANG-4; Angiopoietin-3; ANGPT4; MGC138181; MGC138183
Molecular Weight

35-50 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
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ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His)
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HY-P78237
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