Annexin A13/ANXA13 Protein, Dog (P.pastoris, His)

Annexin A13/ANXA13 protein has a high affinity for folic acid and can bind to reduced folic acid derivatives to promote the transport of 5-methyltetrahydrofolate and folic acid analogs into cells. After endocytosis, the FOLR1 protein undergoes conformational changes when exposed to slightly acidic pH, resulting in a significant reduction in its affinity for folate and subsequent release. Annexin A13/ANXA13 Protein, Dog (P.pastoris, His) is the recombinant dog-derived Annexin A13/ANXA13 protein, expressed by P. pastoris , with N-His labeled tag.

The FOLR1 protein plays a crucial role in cellular processes by binding to folate and reduced folic acid derivatives, facilitating the delivery of 5-methyltetrahydrofolate and folate analogs into the cell interior. With a high affinity for folate and its analogs under neutral pH conditions, the receptor undergoes a conformational change upon exposure to a slightly acidic pH post-endocytosis, leading to a significant reduction in its affinity for folates and subsequent release. This dynamic behavior contributes to its involvement in normal embryonic development and cell proliferation, highlighting its importance in fundamental biological processes.

Dog

P. pastoris

N-His

Q29471-1 (G2-H316)

403935  [NCBI]

Full Length of Isoform-1 Mature Protein

GNRHAKAKSHHGFDVDHDAKKLNKACKGMGTDEAAIIEILSSRTSDERQQIKQKYKATYGKDLEEVFKSDLSGNFEKTALALLDRPSEYDARQLQKAMKGLGTDEAVLIEILCTRTNKEIMAIKEAYQRLFDRSLESDVKADTSGNLKAILVSLLQANRDEGDDVDKDLAGQDAKDLYDAGDGRWGTDELAFNEVLAKRSHKQLRATFQAYQILIDKDIEEAIEAETSGDLQKAYLTLVRCARDQEGYFADRLYKSMKGTGTDEETLIHIIVTRAEVDLQGIKAKFQEKYQKSLSDMVRSDTSGDFQKLLVALLH

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.