B3GNT6 Protein, Human (sf9, His)

B3GNT6 protein is an important β-1,3-N-acetylglucosaminyltransferase, which is essential for the synthesis of O-glycan core 3 structure, and O-glycan is required for mucin-type glycoprotein biosynthesis. Required. B3GNT6 plays a critical role in digestive organs and contributes significantly to the structural diversity and functional properties of glycoconjugates. B3GNT6 Protein, Human (sf9, His) is the recombinant human-derived B3GNT6 protein, expressed by Sf9 insect cells , with N-His labeled tag.

The B3GNT6 Protein functions as a vital beta-1,3-N-acetylglucosaminyltransferase, specializing in the synthesis of the core 3 structure of O-glycans, which serves as a crucial precursor in the biosynthesis of mucin-type glycoproteins. With a key role in the synthesis of mucin-type O-glycans, particularly in digestive organs, B3GNT6 contributes significantly to the structural diversity and functional properties of glycoconjugates. The enzyme's involvement in core 3 O-glycan synthesis is essential for the proper formation and function of mucins, influencing processes related to cell adhesion and mucosal protection. Understanding the specific role of B3GNT6 enhances our comprehension of glycosylation pathways, offering potential applications in elucidating digestive organ physiology and contributing to the exploration of glycan-related therapeutic targets. Further investigation into B3GNT6's function holds promise for advancing our knowledge of mucin-type glycoprotein biosynthesis and its implications in health and disease.

Human

Sf9 insect cells

N-His

Q6ZMB0-1 (Q44-S384)

192134  [NCBI]

Partial

QEETPEGPTDAPAADEPPSELVPGPPCVANASANATADFEQLPARIQDFLRYRHCRHFPLLWDAPAKCAGGRGVFLLLAVKSAPEHYERRELIRRTWGQERSYGGRPVRRLFLLGTPGPEDEARAERLAELVALEAREHGDVLQWAFADTFLNLTLKHLHLLDWLAARCPHARFLLSGDDDVFVHTANVVRFLQAQPPGRHLFSGQLMEGSVPIRDSWSKYFVPPQLFPGSAYPVYCSGGGFLLSGPTARALRAAARHTPLFPIDDAYMGMCLERAGLAPSGHEGIRPFGVQLPGAQQSSFDPCMYRELLLVHRFAPYEMLLMWKALHSPALSCDRGHRVS

Approximately 47 kDa, based on SDS-PAGE under reducing conditions.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.

• [1]. /biology-dictionary/thp-1-cell.html  [Content Brief]