Calcitonin/CALCA Protein, Human (HEK293, Fc)

Calcitonin, encoded by the CALCA gene, causes a rapid and transient decrease in blood calcium and phosphate levels by promoting the incorporation of these ions into bone. This physiological response highlights the role of calcitonin in regulating mineral homeostasis and underlines its impact on skeletal dynamics. Calcitonin/CALCA Protein, Human (HEK293, Fc) is the recombinant human-derived Calcitonin/CALCA protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Calcitonin/CALCA Protein, Human (HEK293, Fc) is 116 a.a., with molecular weight of 40-48 kDa.

Calcitonin, encoded by the CALCA gene, induces a rapid yet transient reduction in blood calcium and phosphate levels by facilitating the incorporation of these ions into bones. This hormone plays a crucial role in calcium homeostasis, functioning as a counter-regulatory mechanism to maintain balanced mineral levels in the bloodstream. Additionally, katacalcin, a peptide derived from the CALCA gene, is identified as a potent plasma calcium-lowering factor. The ability of calcitonin to modulate bone resorption and regulate circulating mineral concentrations underscores its significance in skeletal health and systemic mineral balance. Further exploration of the molecular pathways involved in these actions may contribute to a deeper understanding of calcitonin's role and potential therapeutic applications in conditions related to abnormal calcium metabolism.

Human

HEK293

C-hFc

P01258 (A26-N141)

796  [NCBI]

40-48 kDa

• 
  Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.