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  5. Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO)

Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO)

Cat. No.: HY-P700614
COA Handling Instructions

Calcitonin/CALCA protein acts as a vasodilator, dilating different blood vessels, including coronary, cerebral, and systemic vessels. Its presence in the central nervous system suggests its potential role as a neurotransmitter or neuromodulator. Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO) is the recombinant human-derived Calcitonin/CALCA protein, expressed by P. pastoris , with N-SUMO, N-6*His labeled tag. The total length of Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO) is 37 a.a., with molecular weight of 22 kDa.

For research use only. We do not sell to patients.

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Description

Calcitonin/CALCA protein acts as a vasodilator, dilating different blood vessels, including coronary, cerebral, and systemic vessels. Its presence in the central nervous system suggests its potential role as a neurotransmitter or neuromodulator. Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO) is the recombinant human-derived Calcitonin/CALCA protein, expressed by P. pastoris , with N-SUMO, N-6*His labeled tag. The total length of Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO) is 37 a.a., with molecular weight of 22 kDa.

Background

Calcitonin/CALCA protein, known for its role as a vasodilator, induces dilation in various vessels, including those in the coronary, cerebral, and systemic vasculature. Its presence in the central nervous system suggests potential functions as a neurotransmitter or neuromodulator. Additionally, Calcitonin/CALCA contributes to the elevation of platelet cAMP, indicating its involvement in regulating intracellular signaling pathways. The multifaceted actions of Calcitonin/CALCA underscore its significance in vascular regulation and neurotransmission within the central nervous system.

Species

Human

Source

P. pastoris

Tag

N-SUMO;N-6*His

Accession

P06881 (A83-F119)

Gene ID

796  [NCBI]

Molecular Construction
N-term
6*His-SUMO
CALCA (A83-F119)
Accession # P06881
C-term
Synonyms
CALCA; CALC1Calcitonin gene-related peptide 1; Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I
AA Sequence

ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF

Molecular Weight

22 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder

Formulation

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO)
Cat. No.:
HY-P700614
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