1. Recombinant Proteins
  2. CD127/IL-7RA Protein, Human (HEK293, Fc)

CD127/IL-7RA Protein, Human (HEK293, Fc)

Cat. No.: HY-P7785
Handling Instructions

CD127/IL-7RA Protein, Human (HEK293, Fc) is a recombinant human CD127 expressed in HEK 293 cells with C-Fc-His tag. CD127/IL-7RA Protein is vital for normal T-cell development and survival of most mature T cells[1].

For research use only. We do not sell to patients.

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  • Technical Parameters

  • Properties

  • Documentation

Synonyms
rHuCD127, C-Fc, His; Interleukin-7 receptor subunit alpha; IL7R; IL-7R-alpha; CD127
Species

Human

Source

HEK 293

Accession

P16871 (E21-G236)

Gene ID

3575

Molecular Weight

Approximately 75 kDa

AA Sequence

ESGYAQNGDLEDAELDDYSFSCYSQLEVNGSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRKLQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIVKPEAPFDLSVVYREGANDFVVTFNTSHLQKKYVKVLMHDVAYRQEKDENKWTHVNLSSTKLTLLQRKLQPAAMYEIKVRSIPDHYFKGFWSEWSPSYYFRTPEINNSSG-Fc-HHHHHH

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Biological Activity
Data is not available.
Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O or PBS.

Storage & Stability

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Background

Interleukin-7 receptor (IL-7R) consists of two chains, the IL-7R α-chain (IL-7Rα; also known as CD127) and the common cytokine-receptor γ-chain (γc; also known as CD132), the intracellular domains of which are bound to the tyrosine kinases Janus kinase 1 (JAK1) and JAK3, respectively. IL-7Rα is almost exclusively expressed by cells of the lymphoid lineage, in which it has crucial functions. IL-7Rα plays an important role in lymphocyte differentiation, proliferation, and survival[1].

Documentation
References
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Product Name:
CD127/IL-7RA Protein, Human (HEK293, Fc)
Cat. No.:
HY-P7785
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