CD200R1 Protein, Human (HEK293, His)
CD200R1 protein is an inhibitory receptor that regulates key interactions by binding to the CD200/OX2 glycoprotein, thereby limiting inflammation by inhibiting TNF-α, interferons, and iNOS. CD200R1 Protein, Human (HEK293, His) is the recombinant human-derived CD200R1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
CD200R1 protein is an inhibitory receptor that regulates key interactions by binding to the CD200/OX2 glycoprotein, thereby limiting inflammation by inhibiting TNF-α, interferons, and iNOS. CD200R1 Protein, Human (HEK293, His) is the recombinant human-derived CD200R1 protein, expressed by HEK293 , with C-6*His labeled tag.
Background
CD200R1 is an inhibitory receptor that acts as a key regulator by binding to the CD200/OX2 cell surface glycoprotein. Its regulatory role extends to limiting inflammation in response to specific stimuli by inhibiting pro-inflammatory molecules including TNF-α, interferons, and inducible nitric oxide synthase (iNOS). CD200R1 exhibits comparable affinity and kinetics when binding to the human herpesvirus 8 K14 viral CD200 homolog. The interaction between CD200 and CD200R1 is facilitated by their respective N-terminal Ig-like domains. In addition, CD200R1 binds to the human herpesvirus 8 vOX2 protein, further extending its multifunctional interactions in cellular processes.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
Q8TD46-4 (A27-L266)
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Molecular Construction
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N-term
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CD200R1 (A27-L266)
Accession # Q8TD46-4 -
6*His
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C-term
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Protein Length
Extracellular Domain
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Synonyms
CD200R1; CD200 Cell Surface Glycoprotein Receptor; Prev. MOX2R; MOX2 Receptor; CD200R; Cell Surface Glycoprotein Receptor CD200; OX2R; CD200R1 Protein; HCRTR2; CRTR2; Cell Surface Glycoprotein CD200 Receptor 1; CD200 Receptor 1; Cell Surface Glycoprotein
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AA Sequence
AAQPNNSLMLQTSKENHALASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTDERITWVSRPDQNSDLQIRTVAITHDGYYRCIMVTPDGNFHRGYHLQVLVTPEVTLFQNRNRTAVCKAVAGKPAAHISWIPEGDCATKQEYWSNGTVTVKSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKL
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Predicted Molecular Mass
27.8 kDa
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Molecular Weight
Approximately 48-80 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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