CD200R1 Protein, Human (HEK293, His-Fc)

CD200R1 protein is an inhibitory receptor that regulates key interactions by binding to the CD200/OX2 glycoprotein, thereby limiting inflammation by inhibiting TNF-α, interferons, and iNOS. CD200R1 Protein, Human (HEK293, His-Fc) is the recombinant human-derived CD200R1 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

CD200R1 is an inhibitory receptor that acts as a key regulator by binding to the CD200/OX2 cell surface glycoprotein. Its regulatory role extends to limiting inflammation in response to specific stimuli by inhibiting pro-inflammatory molecules including TNF-α, interferons, and inducible nitric oxide synthase (iNOS). CD200R1 exhibits comparable affinity and kinetics when binding to the human herpesvirus 8 K14 viral CD200 homolog. The interaction between CD200 and CD200R1 is facilitated by their respective N-terminal Ig-like domains. In addition, CD200R1 binds to the human herpesvirus 8 vOX2 protein, further extending its multifunctional interactions in cellular processes.

Human

HEK293

C-hFc;C-His

Q8TD46-4 (A27-L266)

131450  [NCBI]

Partial

AAQPNNSLMLQTSKENHALASSSLCMDEKQITQNYSKVLAEVNTSWPVKMATNAVLCCPPIALRNLIIITWEIILRGQPSCTKAYKKETNETKETNCTDERITWVSRPDQNSDLQIRTVAITHDGYYRCIMVTPDGNFHRGYHLQVLVTPEVTLFQNRNRTAVCKAVAGKPAAHISWIPEGDCATKQEYWSNGTVTVKSTCHWEVHNVSTVTCHVSHLTGNKSLYIELLPVPGAKKSAKL

Approximately 90-100 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.