CD96 Protein, Cynomolgus (HEK293, His)

CD96 protein is a type I membrane protein. This protein may play a role in the adhesion interaction between activated T cells and NK cells in the late stage of immune response. It may also play a role in antigen presentation. CD155 acts as the main ligand of the CD96 receptor. CD96 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD96 protein, expressed by HEK293 , with C-His labeled tag.

The proteins encoded by the CD96 gene belong to the immunoglobulin superfamily. It is a type I membrane protein. This protein may play a role in the adhesion interaction between activated T cells and NK cells in the late stage of immune response. It may also play a role in antigen presentation. CD155 acts as the main ligand of the CD96 receptor. CD96 mediates the adhesion of NK cells to cells expressing myeloid virus receptor (PVR)/CD155 and promotes their interaction, thereby stimulating the cytotoxic activity of NK cells. This pre-adhesion property of CD96 and the high expression of PVR in some tumors contribute to tumor recognition by NK cells and tumor cell death^[1][2].

Cynomolgus

HEK293

C-8*His

A0A2K5TWV6 (V22-G502)

102121080

Partial

VWGKPFNTEENIYATLGSDVNLTCQTQAKGFLVQMQWSKVTDKADLIALYHPQYGFHCAYGSPCESLVTFTQTPENGSKWTLHLRNMSSSVSGRYECMLTLYPEGMQTKIYNLLIQTHVTPDEWKSNHTIEIEINQTLEIPCFQNSSSEISSEFTYAWLVEDNGTQQTLISQDHLISSSTLLKDRVKVGTDSRLHLSPVQIFDDGRKFSCHIRVGPDKILRSSTTIKVFAKPEIPMIVENNSTDVLVERTFTCLLKNVFPKANIIWFIDGSFLHDEKEGIYITNEERKGKDGFLELKSVLTRVHSDKPAQSDNLTIWCMALSPVPGNKVWNISSEKITFLLGSEMSTTDPPPSVTESTLDTQPSPASSVSPTRYPATSSVTLADVSALRPNTTPQSSSSSVTTQDFNYPWTSSGTDAKKSFSQIPSETYSSSPSGAGSTLHDNVFTSTTRAFSEVPTTANGSTKTNHVHITGIVVSKPKDG

Approximately 80-130 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.