Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His)

Claudin-18/CLDN18.2 Protein-VLP, Mouse (HEK293, His) is recommended for animal immunization, ELISA. It is not recommended for receptor-ligand interaction detection and SPR/BLI assay since there are other irrelevant membrane proteins of the host on the VLP envelope, and the receptor-ligand interaction will have strong background interference. High requirements for chips and experimental protocols are needed for SPR/BLI assays. If VLP control is required, it is recommended HY-P701236. Tags can only be detected under denaturing conditions.

Claudin-18/CLDN18 Protein-VLP assumes a pivotal role in establishing the gastric paracellular barrier by actively participating in the formation of tight junctions. This essential function positions it as a key contributor to the intricate network that regulates the permeability of gastric epithelial cells. Through its involvement in tight junction assembly, Claudin-18/CLDN18 Protein-VLP plays a crucial role in orchestrating the cellular response to gastric acidification. This intricate molecular mechanism ensures the integrity and selective permeability of the gastric barrier, safeguarding the underlying tissues from the corrosive effects of gastric acid.

Mouse

HEK293

N-6*His

P56857-3 (M1-V264)

56492  [NCBI]

Full Length of Isoform A2.1

MSVTACQGLGFVVSLIGFAGIIAATCMDQWSTQDLYNNPVTAVFNYQGLWRSCVRESSGFTECRGYFTLLGLPAMLQAVRALMIVGIVLGVIGILVSIFALKCIRIGSMDDSAKAKMTLTSGILFIISGICAIIGVSVFANMLVTNFWMSTANMYSGMGGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLTPDDSNFKAVSYHASGQNVAYRPGGFKASTGFGSNTRNKKIYDGGARTEDDEQSHPTKYDYV

Purity analysis by SDS-PAGE is not available for VLP proteins.

<1 EU/μg, determined by LAL method.