COL4A3 Protein, Rat (HEK293, Fc)

The COL4A3 protein is a key type IV collagen component that forms the major structural element of the glomerular basement membrane (GBM). It collaborates with laminin, proteoglycans, and nestin/nesidin to create a "chicken wire" network that is critical for maintaining the structural integrity of the GBM. COL4A3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived COL4A3 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of COL4A3 Protein, Rat (HEK293, Fc) is 245 a.a., with molecular weight of ~59 kDa.

COL4A3 protein, a crucial constituent of Type IV collagen, serves as the primary structural element in glomerular basement membranes (GBM), where it collaborates with laminins, proteoglycans, and entactin/nidogen to create a 'chicken-wire' meshwork. This intricate network plays a fundamental role in maintaining the structural integrity and stability of GBMs, essential for their proper functioning in renal physiology. COL4A3's involvement in the formation of the meshwork underscores its significance in supporting the integrity of glomerular basement membranes, pivotal for renal function and homeostasis.

Rat

HEK293

N-hFc

F1LRJ1 (G1426-H1670)

363265  [NCBI]

Approximately 59 kDa

Greater than 85% as determined by reducing SDS-PAGE

Solution.

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.